Glutathione Peroxidase 4 (Phospholipid Hydroperoxide Glutathione Peroxidase, PHGPx)
Glutathione Peroxidase 4 (Phospholipid Hydroperoxide Glutathione Peroxidase, PHGPx)
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重點
Glutathione Peroxidase 4 (Phospholipid Hydroperoxide Glutathione Peroxidase, PHGPx) can directly reduce phospholipid hydroperoxide. Depletion of GPx4 induces lipid peroxidation-dependent cell death in embryo, testis, brain, liver, heart, and photoreceptor cells of mice. Administration of Vitamin E in tissue specific GPx4 KO mice restored tissue damage in testis, liver, and heart. These results indicate that suppression of phospholipid peroxidation is essential for cell survival in normal tissues in mice.
資訊來源：
Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis PY2017 IR95 Glutathione 教材，日本
https://pubmed.ncbi.nlm.nih.gov/28204974/
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資訊來源 (Info Source)：
The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities PY2022 IR95 教材 P03E
資訊來源 (Info Source)：
The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities PY2022 IR95 教材 P03E
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資訊來源：
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Placeholder 湯偉晉編寫的英文字典
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