The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19 PY2020 IR95 higher calcium influx into the vessel wall

The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19 PY2020 IR95 higher calcium influx into the vessel wall

The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19 PY2020 IR95

Info or Reference Source (資訊或是參考資訊的來源), as of D2022-0701-WD5： 

https://pubmed.ncbi.nlm.nih.gov/32708578/

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#重要的知識：醫學：科學：重要等級 IR95 ：關鍵字 Keywords KeyWordS：重點開始：WJD 2022-0701：

the combination low GSH/low NO leads to a higher calcium influx into the vessel wall and in smooth muscle with vasoconstriction

Hypertension. Diabetes and hypertension seem to be the most frequent comorbidities in dying patients [74]. Hypertension may depend on multiple factors; among them it is relevant to cite the activation of the renin-angiotensin system mainly by renin overexpression secondary to low vitamin D, the decreased activity of eNOS and the decreased levels of GSH. As already described for diabetes, the combination low GSH/low NO leads to a higher calcium influx into the vessel wall and in smooth muscle with vasoconstriction, as demonstrated also in animal models [75]. Since in hypertensive patients the low levels of GSH are often accompanied by a decrease of companion enzymes (catalase, GSH-peroxidase and GST) and increased lipid peroxides, the prevailing hypothesis is that the GSH decrease is due to a burst of ROS production, secondary to an inflammatory process [76]. It has been demonstrated that GSH depletion induces chronic oxidative stress and causes hypertension in normal rats. This is accompanied by inactivation and sequestration of NO by ROS, leading to diminished NO bioavailability [77].

重點 Tang , WeiJin 重點結束 

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