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2021-01-16
Pathways of mitochondrial
GSH transport
Source (資訊來源):
https://pubs.rsc.org/en/content/articlehtml/2012/tx/c2tx20021j
Info cited on 2021-01-16-WD6 (資訊引用於 中華民國110年西元2021年1月16日) by 湯偉晉 (WeiJin Tang)
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Pathways of mitochondrial
GSH transport
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Fig.
3 Pathways
of mitochondrial GSH
transport. Two carriers on the mitochondrial inner membrane of renal cortex, the dicarboxylate carrier
(DIC; Slc25a10) and 2-oxoglutarate carrier (OGC; Slc25a11), are
responsible for most of the observable transport of GSH from cytoplasm into mitochondrial matrix. The
DIC can exchange GSH for inorganic
phosphate (Pi2−)
whereas the OGC exchanges GSH for 2-oxoglutarate (2-OG). Both transport processes integrate with and are critical
for the citric acid cycle, pyridine nucleotides, and maintenance of redox
homeostasis. |
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Pathways of mitochondrial GSH transport
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