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湯偉晉 (WeiJin Tang) 編寫的字典 (電子郵件: WeiJin.Tang@gmail.com)(行動電話_湯偉晉_0958-227-243_as_of_2011-01-09_) English-Chinese Online Dictionary,英文-中文 線上字典(詞典),中英字典,英中字典,中英文字典, English Dictionary by WeiJin Tang (湯偉晉 編寫的英文字典)
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Quemoy University (金門大學)
校訓
真知力行 兼善天下
秉承校訓「真知力行、兼善天下」,研訂教育目標為「落實全人均衡發展、培養理論及實務兼具之專業人才」。
National Quemoy University
真知 - 以博學、審問、慎思、明辨方法,追求科學真理。
力行 - 以即知即行、手腦並用的態度,貫徹學以致用。
兼善天下 - 求學目的不僅僅在提升自己,而且要能造福人群。
discuss (討論)
discussed (討論)
discuss (討論)
discussed (討論)
The below is attributable to Spokesperson Tammy Bruce:
以下的內容由 發言人 塔米·布魯斯 提供:
Glutathione-Scavenging Celastrol-Cu Nanoparticles Induce Self-Amplified Cuproptosis for Augmented Cancer Immunotherapy PY2024 IR95 教材
資訊來源:
https://pubmed.ncbi.nlm.nih.gov/38935977/
Cuproptosis (銅凋亡)
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Sheng Lu et al. Adv Mater. 2024 Aug.
Cuproptosis is a novel copper-dependent programmed cell death. The efficacy of cuproptosis is highly dependent on intracellular copper accumulation and counteracted by a high level of glutathione (GSH) in tumor cells. Here, this work develops a self-amplified cuproptosis nanoparticles (Cel-Cu NP) using celastrol (Cel), a natural product isolated from medical plant. In Cel-Cu NP, Cel serves as a versatile copper ionophore, exhibiting an ideal coordination capacity toward copper ions without compromising the cuproptosis induction. Notably, Cel can simultaneously scavenge GSH content to amplify cuproptosis. Moreover, this self-amplified cuproptosis further activates immunogenic cell death (ICD) to elicit robust immune response. Combining with immune checkpoint blockade, Cel-Cu NP effectively eradicates metastatic tumors in a mouse lung metastasis model. This study provides an efficient nanomedicine by inducing self-amplified cuproptosis for robust immunotherapy.
Keywords: cancer immunotherapy; celastrol; cuproptosis; glutathione‐scavenging; immunogenic cell death.
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