在 甲狀腺癌患者 的 血清中 總 氧化劑/抗氧化劑 的狀態
Total oxidant/antioxidant status in sera of patients with thyroid cancers (在 甲狀腺癌患者 的 血清中 總 氧化劑/抗氧化劑 的狀態)
在 甲狀腺癌患者 的 血清中 總 氧化劑/抗氧化劑 的狀態 (Total oxidant/antioxidant status in sera of patients with thyroid cancers)
Placeholder 湯偉晉編寫的英文字典
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2024-07-16
Total oxidant/antioxidant status in sera of patients with thyroid cancers
在 甲狀腺癌患者 的 血清中 總 氧化劑/抗氧化劑 的狀態
Source or References (資訊來源或是參考的資訊):
https://pubmed.ncbi.nlm.nih.gov/22002574/
Info cited on 2024-07-16-WD2 (資訊引用於 中華民國113年西元2024年7月16日) by 湯偉晉 (WeiJin Tang)
#
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Endocr Relat Cancer
2011 Dec 1;18(6):773-82. doi: 10.1530/ERC-11-0230. Print 2011 Dec.
Total oxidant/antioxidant status in sera of patients with thyroid cancers
Dong Wang 1, Jia-Fu Feng, Ping Zeng, Yun-Hong Yang, Jun Luo, Yu-Wei Yang
Affiliation
1Department of Oncology, Mianyang Central Hospital, Mianyang, Sichuan Province, China.
PMID: 22002574 PMCID: PMC3230112 DOI: 10.1530/ERC-11-0230
Abstract
Oxidative stress is considered to be involved in the pathophysiology of all cancers. In order to evaluate the total oxidant/antioxidant status in patients with thyroid cancer and to investigate the relationship between oxidative stress parameters and serum thyroid profiles among thyroid cancer patients and various controls, we determined oxidative status including total antioxidant status (TAS) and total oxidant status (TOS) and calculation of oxidative stress index (OSI) in sera in 82 thyroid cancer patients, 56 benign thyroid disease patients, and 50 healthy controls. It was found that serum TAS levels were significantly lower in patients with thyroid cancer than in controls (P<0.001), while serum TOS levels and OSI values were significantly higher (both P<0.001) in the cancer patients. No significant correlations were observed between various oxidative stress markers and thyroid profiles in either the thyroid cancer patients or the controls. Receiver operating characteristic curve analysis demonstrated that OSI was the best indicator for distinguishing cancer patients from benign thyroid diseased or healthy controls, followed by TOS and TAS. Risk estimate statistics also indicated that TOS and/or OSI were good risk factors to discriminate patients with thyroid cancer from two controls. These findings suggested that oxidants are increased and antioxidants are decreased in patients with thyroid cancer. OSI may be a more useful oxidative stress biomarker than TAS and TOS for monitoring the clinical status of thyroid cancer patients.
Begin_電腦自動翻譯的內容_Y2024M07D16H03M17Rn6827_
(請注意：電腦自動翻譯的內容，可能會夾雜一些錯誤！)
氧化壓力被認為與所有癌症的病理生理學有關。為了評估甲狀腺癌患者的總氧化/抗氧化狀態，並探討甲狀腺癌患者和不同對照者氧化壓力參數與血清甲狀腺光譜之間的關係，我們測定了氧化狀態，包括總氧化狀態（TAS）和總氧化程度。結果發現，甲狀腺癌患者血清TAS水準顯著低於對照組（P<0.001），而癌症患者血清TOS水準和OSI值顯著上升（均P<0.001）。在甲狀腺癌患者或對照組中，各種氧化壓力標記與甲狀腺特徵之間沒有觀察到顯著相關性。受試者工作特徵曲線分析表明，OSI 是區分癌症患者與良性甲狀腺疾病或健康對照組的最佳指標，其次是 TOS 和 TAS。風險估計統計數據還表明，TOS 和/或 OSI 是區分甲狀腺癌患者與兩名對照患者的良好風險因素。這些發現表明，甲狀腺癌患者體內的氧化劑增加，抗氧化劑減少。 OSI 可能是比 TAS 和 TOS 更有用的氧化壓力生物標記物，用於監測甲狀腺癌患者的臨床狀態。
End_電腦自動翻譯的內容_Y2024M07D16H03M17Rn6827_
Comment in
Oxidative stress: a new risk factor for thyroid cancer.
Xing M.
PMID: 22143496
Similar articles
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Front Oncol. 2023 Oct 30
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Influence of the circadian cycle, sex and production stage on the reference values of parameters related to stress and pathology in porcine saliva.
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Porcine Health Manag. 2023 Sep 29;9(1):42. doi: 10.1186/s40813-023-00337-7.
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MiR-146b-5p regulates the scavenging effect of GPx-3 on peroxide in papillary thyroid cancer cells.
Zhang D, Deng JJ, Xu Q, Zeng Y, Jiang J.
Heliyon. 2023 Jul 20;9(8):e18489. doi: 10.1016/j.heliyon.2023.e18489. eCollection 2023 Aug.
PMID: 37533981
Could Oxidative Stress Play a Role in the Development and Clinical Management of Differentiated Thyroid Cancer?
Kościuszko M, Buczyńska A, Krętowski AJ, Popławska-Kita A.
Cancers (Basel). 2023 Jun 14;15(12):3182. doi: 10.3390/cancers15123182.
PMID: 37370792 Review.
See all "Cited by" articles
References
Abiaka C, Al-Awadi F, Al-Sayer H, Gulshan S, Behbehani A, Farghally M, Simbeye A. Serum antioxidant and cholesterol levels in patients with different types of cancer. Journal of Clinical Laboratory Analysis. 2001;15:324–330. doi: 10.1002/jcla.1045. - DOI - PMC - PubMed
Akinci M, Kosova F, Cetin B, Sepici A, Altan N, Aslan S, Cetin A. Oxidant/antioxidant balance in patients with thyroid cancer. Acta Cirúrgica Brasileira. 2008;23:551–554. doi: 10.1590/S0102-86502008000600013. - DOI - PubMed
Alkhenizan A, Hafez K. The role of vitamin E in the prevention of cancer: a meta-analysis of randomized controlled trials. Annals of Saudi Medicine. 2007;27:409–414. doi: 10.4103/0256-4947.51459. - DOI - PMC - PubMed
Andryskowski G, Owczarek T. The evaluation of selected oxidative stress parameters in patients with hyperthyroidism. Polskie Archiwum Medycyny Wewnetrznej. 2007;117:285–289. - PubMed
Aslan M, Cosar N, Celik H, Aksoy N, Dulger AC, Begenik H, Soyoral YU, Kucukoglu ME, Selek S. Evaluation of oxidative status in patients with hyperthyroidism. Endocrine. 2011;40:285–289. doi: 10.1007/s12020-011-9472-3. - DOI - PubMed
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--- --- - - --- ---
2024-07-16
Total oxidant/antioxidant status in sera of patients with thyroid cancers
在 甲狀腺癌患者 的 血清中 總 氧化劑/抗氧化劑 的狀態
Source or References (資訊來源或是參考的資訊):
https://pubmed.ncbi.nlm.nih.gov/22002574/
Info cited on 2024-07-16-WD2 (資訊引用於 中華民國113年西元2024年7月16日) by 湯偉晉 (WeiJin Tang)
#
- - - - - - - -
Endocr Relat Cancer
2011 Dec 1;18(6):773-82. doi: 10.1530/ERC-11-0230. Print 2011 Dec.
Total oxidant/antioxidant status in sera of patients with thyroid cancers
Dong Wang 1, Jia-Fu Feng, Ping Zeng, Yun-Hong Yang, Jun Luo, Yu-Wei Yang
Affiliation
1Department of Oncology, Mianyang Central Hospital, Mianyang, Sichuan Province, China.
PMID: 22002574 PMCID: PMC3230112 DOI: 10.1530/ERC-11-0230
Abstract
Oxidative stress is considered to be involved in the pathophysiology of all cancers. In order to evaluate the total oxidant/antioxidant status in patients with thyroid cancer and to investigate the relationship between oxidative stress parameters and serum thyroid profiles among thyroid cancer patients and various controls, we determined oxidative status including total antioxidant status (TAS) and total oxidant status (TOS) and calculation of oxidative stress index (OSI) in sera in 82 thyroid cancer patients, 56 benign thyroid disease patients, and 50 healthy controls. It was found that serum TAS levels were significantly lower in patients with thyroid cancer than in controls (P<0.001), while serum TOS levels and OSI values were significantly higher (both P<0.001) in the cancer patients. No significant correlations were observed between various oxidative stress markers and thyroid profiles in either the thyroid cancer patients or the controls. Receiver operating characteristic curve analysis demonstrated that OSI was the best indicator for distinguishing cancer patients from benign thyroid diseased or healthy controls, followed by TOS and TAS. Risk estimate statistics also indicated that TOS and/or OSI were good risk factors to discriminate patients with thyroid cancer from two controls. These findings suggested that oxidants are increased and antioxidants are decreased in patients with thyroid cancer. OSI may be a more useful oxidative stress biomarker than TAS and TOS for monitoring the clinical status of thyroid cancer patients.
Begin_電腦自動翻譯的內容_Y2024M07D16H03M17Rn6827_
(請注意：電腦自動翻譯的內容，可能會夾雜一些錯誤！)
氧化壓力被認為與所有癌症的病理生理學有關。為了評估甲狀腺癌患者的總氧化/抗氧化狀態，並探討甲狀腺癌患者和不同對照者氧化壓力參數與血清甲狀腺光譜之間的關係，我們測定了氧化狀態，包括總氧化狀態（TAS）和總氧化程度。結果發現，甲狀腺癌患者血清TAS水準顯著低於對照組（P<0.001），而癌症患者血清TOS水準和OSI值顯著上升（均P<0.001）。在甲狀腺癌患者或對照組中，各種氧化壓力標記與甲狀腺特徵之間沒有觀察到顯著相關性。受試者工作特徵曲線分析表明，OSI 是區分癌症患者與良性甲狀腺疾病或健康對照組的最佳指標，其次是 TOS 和 TAS。風險估計統計數據還表明，TOS 和/或 OSI 是區分甲狀腺癌患者與兩名對照患者的良好風險因素。這些發現表明，甲狀腺癌患者體內的氧化劑增加，抗氧化劑減少。 OSI 可能是比 TAS 和 TOS 更有用的氧化壓力生物標記物，用於監測甲狀腺癌患者的臨床狀態。
End_電腦自動翻譯的內容_Y2024M07D16H03M17Rn6827_
Comment in
Oxidative stress: a new risk factor for thyroid cancer.
Xing M.
PMID: 22143496
Similar articles
Sera total oxidant/antioxidant status in lung cancer patients.
Xiang M, Feng J, Geng L, Yang Y, Dai C, Li J, Liao Y, Wang D, Du XB.
Medicine (Baltimore). 2019 Sep
PMID: 31517874
Total Oxidant/Antioxidant Status in Sera of Patients with Esophageal Cancer.
Huang Q, Feng J, Wu R, Yang Y, Dai C, Li J, Liao Y, Xiang M, Wang D, Du XB.
Med Sci Monit. 2017 Aug 4
PMID: 28777781
Papillary Thyroid Carcinoma: A Malignant Tumor with Increased Antioxidant Defense Capacity.
Rovcanin BR, Gopcevic KR, Kekic DLj, Zivaljevic VR, Diklic ADj, Paunovic IR.
Tohoku J Exp Med. 2016 Oct
PMID: 27615359
Analysis of the diagnostic efficiency of serum oxidative stress parameters in patients with breast cancer at various clinical stages.
Feng JF, Lu L, Dai CM, Wang D, Yang YH, Yang YW, Liu YS.
Clin Biochem. 2016 Jun
PMID: 26899366
Evaluation of total oxidant and antioxidant status in localized and generalized vitiligo.
Akoglu G, Emre S, Metin A, Akbas A, Yorulmaz A, Isikoglu S, Sener S, Kilinc F.
Clin Exp Dermatol. 2013 Oct
PMID: 23601201
Cited by
Monitoring Metastatic Colorectal Cancer Progression According to Reactive Oxygen Metabolite Derivative Levels.
Sawai K, Goi T, Kimura Y, Koneri K.
Cancers (Basel). 2023 Nov 22
PMID: 38067221
Analysis of redox status and HDL subclasses in patients with lymphoma and the associations with FDG-PET/CT findings.
Mirjanic-Azaric B, Stankovic S, Nezic L, Radic Savic Z, Malcic-Zanic D, Skrbic R, Kotur-Stevuljevic J, Bogavac-Stanojevic N.
Front Oncol. 2023 Oct 30
PMID: 37965473
Influence of the circadian cycle, sex and production stage on the reference values of parameters related to stress and pathology in porcine saliva.
Saco Y, Peña R, Matas-Quintanilla M, Ibáñez-López FJ, Piñeiro M, Sotillo J, Bassols A, Gutiérrez AM.
Porcine Health Manag. 2023 Sep 29;9(1):42. doi: 10.1186/s40813-023-00337-7.
PMID: 37773175
MiR-146b-5p regulates the scavenging effect of GPx-3 on peroxide in papillary thyroid cancer cells.
Zhang D, Deng JJ, Xu Q, Zeng Y, Jiang J.
Heliyon. 2023 Jul 20;9(8):e18489. doi: 10.1016/j.heliyon.2023.e18489. eCollection 2023 Aug.
PMID: 37533981
Could Oxidative Stress Play a Role in the Development and Clinical Management of Differentiated Thyroid Cancer?
Kościuszko M, Buczyńska A, Krętowski AJ, Popławska-Kita A.
Cancers (Basel). 2023 Jun 14;15(12):3182. doi: 10.3390/cancers15123182.
PMID: 37370792 Review.
See all "Cited by" articles
References
Abiaka C, Al-Awadi F, Al-Sayer H, Gulshan S, Behbehani A, Farghally M, Simbeye A. Serum antioxidant and cholesterol levels in patients with different types of cancer. Journal of Clinical Laboratory Analysis. 2001;15:324–330. doi: 10.1002/jcla.1045. - DOI - PMC - PubMed
Akinci M, Kosova F, Cetin B, Sepici A, Altan N, Aslan S, Cetin A. Oxidant/antioxidant balance in patients with thyroid cancer. Acta Cirúrgica Brasileira. 2008;23:551–554. doi: 10.1590/S0102-86502008000600013. - DOI - PubMed
Alkhenizan A, Hafez K. The role of vitamin E in the prevention of cancer: a meta-analysis of randomized controlled trials. Annals of Saudi Medicine. 2007;27:409–414. doi: 10.4103/0256-4947.51459. - DOI - PMC - PubMed
Andryskowski G, Owczarek T. The evaluation of selected oxidative stress parameters in patients with hyperthyroidism. Polskie Archiwum Medycyny Wewnetrznej. 2007;117:285–289. - PubMed
Aslan M, Cosar N, Celik H, Aksoy N, Dulger AC, Begenik H, Soyoral YU, Kucukoglu ME, Selek S. Evaluation of oxidative status in patients with hyperthyroidism. Endocrine. 2011;40:285–289. doi: 10.1007/s12020-011-9472-3. - DOI - PubMed
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Placeholder 湯偉晉編寫的英文字典
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