polyol pathway

polyol pathway

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Polyol pathway flux and aldose reductase.

Over the past 50 years, circumstantial33 and experimental34 evidence has established hyperglycaemia-driven increases in flux through the polyol pathway as the best-understood pathogenic mechanism of diabetic neuropathy. Numerous preclinical studies have demonstrated that inhibition of aldose reductase (the first enzyme in the polyol pathway) prevents almost all manifestations of neuropathy.

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Placeholder 湯偉晉編寫的英文字典

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Placeholder 湯偉晉編寫的英文字典

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