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English-Chinese Online Dictionary,英文-中文 線上字典(詞典),中英字典,英中字典,中英文字典, English Dictionary by WeiJin Tang (湯偉晉 編寫的英文字典)
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2024年2月17日 星期六
mercapturic acid pathway (MAP)
The mercapturic acid pathway (MAP) is a major phase II detoxification route, comprising the conjugation of electrophilic substances to glutathione (GSH) in a reaction catalyzed by glutathione S-transferase (GST) enzymes. In mammals, GSH-conjugates are exported from cells, and the GSH-constituent amino acids (Glu/Gly) are subsequently removed by ectopeptidases. The resulting Cys-conjugates are reabsorbed and, finally, a mercapturic acid is generated through N-acetylation.
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