the base excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1), a DNA repair protein

Redox regulation of DNA repair: implications for human health and cancer therapeutic development. [2010](IR92)

 

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(Memo Item created on August 11, 2012 08:18 PM)

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Redox regulation of DNA repair: implications for human health and cancer therapeutic development.

 

http://www.ncbi.nlm.nih.gov/pubmed/19764832

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Antioxid Redox Signal. 2010 Jun 1;12(11):1247-69.

Redox regulation of DNA repair: implications for human health and cancer therapeutic development.

Luo M, He H, Kelley MR, Georgiadis MM.

Source

Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University, Indiana, USA.

 

Abstract

Redox reactions are known to regulate many important cellular processes. In this review, we focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA repair proteins as well as indirect transcriptional regulation. A key player in the redox regulation of DNA repair is the base excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) in its role as a redox factor. APE1 is reduced by the general redox factor thioredoxin, and in turn reduces several important transcription factors that regulate expression of DNA repair proteins. Finally, we consider the potential for chemotherapeutic development through the modulation of APE1's redox activity and its impact on DNA repair.

 

PMID: 19764832 [PubMed - indexed for MEDLINE] PMCID: PMC2864659 Free PMC Article

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