toxin (毒素)

toxin

毒素

toxin (毒素)

info source (資訊來源), information source (資訊來源)

info source

information source

資訊來源

information source (資訊來源)

info source (資訊來源)

genetic algorithm (基因演算法)

genetic algorithm

基因演算法

genetic algorithm (基因演算法)

基因演算法 (genetic algorithm)

genome (基因組)

genome

基因組

genome (基因組)

human genome

人類基因組

human genome (人類基因組)

微生物基因組

microbe genome

microbe genome (微生物基因組)

genomics

基因組學

genomics (基因組學)

基因組學 (genomics)

genome sequencing

基因組的定序

genome sequencing (基因組的定序)

基因組的定序 (genome sequencing)

comparative genomics

比較基因組學

comparative genomics (比較基因組學)

比較基因組學 (comparative genomics)

carcinogen (致癌物)

carcinogen
致癌物
carcinogen (致癌物)
致癌物 (carcinogen)

#

carcinogen

【醫學名詞】

致癌物(質)，致癌物質

carcinogen (【醫學名詞】致癌物(質)，致癌物質)

the base excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1), a DNA repair protein

Redox regulation of DNA repair: implications for human health and cancer therapeutic development. [2010](IR92)

 

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(Memo Item created on August 11, 2012 08:18 PM)

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Redox regulation of DNA repair: implications for human health and cancer therapeutic development.

 

http://www.ncbi.nlm.nih.gov/pubmed/19764832

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Antioxid Redox Signal. 2010 Jun 1;12(11):1247-69.

Redox regulation of DNA repair: implications for human health and cancer therapeutic development.

Luo M, He H, Kelley MR, Georgiadis MM.

Source

Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University, Indiana, USA.

 

Abstract

Redox reactions are known to regulate many important cellular processes. In this review, we focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA repair proteins as well as indirect transcriptional regulation. A key player in the redox regulation of DNA repair is the base excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) in its role as a redox factor. APE1 is reduced by the general redox factor thioredoxin, and in turn reduces several important transcription factors that regulate expression of DNA repair proteins. Finally, we consider the potential for chemotherapeutic development through the modulation of APE1's redox activity and its impact on DNA repair.

 

PMID: 19764832 [PubMed - indexed for MEDLINE] PMCID: PMC2864659 Free PMC Article

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